Jump to main content
Jump to site search


Synthesis and evaluation of novel O2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents

Author affiliations

Abstract

A group of photochemical nitric oxide (NO) delivery agents, O2-(4-hydroxyphenacyl) diazeniumdiolates 1–2 as well as O2-(3-(benzothiazole-2-yl)-4-hydroxyphenacyl) diazeniumdiolates 3–4, could be triggered by ultraviolet light (365–400 nm) and visible light (≥410 nm), respectively, to produce NO in cancer cells and generate potent antitumor activity. Importantly, with the photolysis of 3 being initiated, the accompanying distinct fluorescence color change (from green to blue) may act as a qualitative real-time optical indicator for NO release in cancer cells.

Graphical abstract: Synthesis and evaluation of novel O2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents

Back to tab navigation

Supplementary files

Publication details

The article was received on 05 Aug 2017, accepted on 05 Sep 2017 and first published on 06 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00695K
Citation: Org. Chem. Front., 2017, Advance Article
  •   Request permissions

    Synthesis and evaluation of novel O2-derived diazeniumdiolates as photochemical and real-time monitoring nitric oxide delivery agents

    X. Luo, J. Wu, T. Lv, Y. Lai, H. Zhang, J. Lu, Y. Zhang and Z. Huang, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00695K

Search articles by author

Spotlight

Advertisements