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Metal-free sequential decarbonylative annulation of N-cyanamides for the construction of 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ones

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Abstract

A convenient metal-free sequential decarbonylative annulation of unactivated alkenes for the construction of quinazolinones and dihydroisoquinolinones has been developed. This strategy features the oxidative decarbonylation of various secondary and tertiary alkyl aldehydes with N-cyanamide alkenes for the cascade construction of C–C/C–N bonds.

Graphical abstract: Metal-free sequential decarbonylative annulation of N-cyanamides for the construction of 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ones

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Publication details

The article was received on 02 Aug 2017, accepted on 01 Sep 2017 and first published on 04 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00677B
Citation: Org. Chem. Front., 2017, Advance Article
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    Metal-free sequential decarbonylative annulation of N-cyanamides for the construction of 2,3-dihydropyrrolo[2,1-b]quinazolin-9(1H)-ones

    X. Liu, P. Qian, Y. Wang and Y. Pan, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00677B

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