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Issue 12, 2017
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Metal-mediated C–O bond forming reactions in natural product synthesis

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Abstract

Metal catalyzed reactions for the formation of C–O bonds have had a dramatic impact in natural product synthesis over the past few decades. Various metals have been reported to efficiently catalyze cross-coupling reactions for the formation of various C(sp2)–O bonds from aryl/alkenyl halides or synthetic equivalents and phenols, aliphatic alcohols and water. The implementation of such reactions in natural product synthesis enabled the emergence of new bond disconnections, which notably resulted in remarkably efficient and short synthetic pathways. The use of these reactions for the formation of C–O bonds in natural product synthesis is overviewed in this critical review, with an emphasis on copper and palladium catalysts which are the most efficient ones to date.

Graphical abstract: Metal-mediated C–O bond forming reactions in natural product synthesis

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Publication details

The article was received on 01 Aug 2017, accepted on 27 Aug 2017 and first published on 29 Aug 2017


Article type: Review Article
DOI: 10.1039/C7QO00671C
Citation: Org. Chem. Front., 2017,4, 2480-2499
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    Metal-mediated C–O bond forming reactions in natural product synthesis

    G. Evano, J. Wang and A. Nitelet, Org. Chem. Front., 2017, 4, 2480
    DOI: 10.1039/C7QO00671C

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