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Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

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Abstract

A diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin with potent anticancer activities was explored. The synthesis was based on a highly efficient gold-catalyzed glycosylation reaction with alkynylbenzoate 3-aminoglycosides as glycosyl donors. According to this strategy, a small library containing digitoxin and digoxin analogues with various 3-aminosugar scaffolds was successfully constructed.

Graphical abstract: Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

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Publication details

The article was received on 28 Jul 2017, accepted on 05 Sep 2017 and first published on 06 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00648A
Citation: Org. Chem. Front., 2017, Advance Article
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    Gold-catalyzed diversified synthesis of 3-aminosugar analogues of digitoxin and digoxin

    J. Zeng, G. Sun, R. Wang, S. Zhang, S. Teng, Z. Liao, L. Meng and Q. Wan, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00648A

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