Jump to main content
Jump to site search

Issue 12, 2017
Previous Article Next Article

Photoredox organocatalytic α-amino C(sp3)–H functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives

Author affiliations

Abstract

A 5-membered heterocyclic γ-amino acid scaffold possesses a wide range of bioactivities. Herein, we report a photoredox organocatalytic, highly selective α-amino C(sp3)–H bond functionalization to generate a reactive α-amino radical, which undergoes conjugate addition to Michael acceptors, providing an elegant intramolecular access to cyclic γ-amino acid analogues in satisfactory yields.

Graphical abstract: Photoredox organocatalytic α-amino C(sp3)–H functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Jul 2017, accepted on 05 Sep 2017 and first published on 06 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00644F
Citation: Org. Chem. Front., 2017,4, 2433-2436
  •   Request permissions

    Photoredox organocatalytic α-amino C(sp3)–H functionalization for the synthesis of 5-membered heterocyclic γ-amino acid derivatives

    J. Liu, J. Xie and C. Zhu, Org. Chem. Front., 2017, 4, 2433
    DOI: 10.1039/C7QO00644F

Search articles by author

Spotlight

Advertisements