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Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

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Abstract

A new method to construct 4-hydroxyalkyl-quinoline derivatives is described via Cu(I) and Au(I) sequential catalyzed cyclization of anilines with aldehyde derivatives and aliphatic alkynes, respectively. The three-component cascade reaction provides an efficient approach for easy access to various new quinoline-based derivatives and quinoline containing an aliphatic chain substituent at the 4-position with high yields.

Graphical abstract: Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

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Publication details

The article was received on 26 Jul 2017, accepted on 13 Oct 2017 and first published on 16 Oct 2017


Article type: Research Article
DOI: 10.1039/C7QO00637C
Citation: Org. Chem. Front., 2017, Advance Article
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    Synthesis of substituted 4-hydroxyalkyl-quinoline derivatives by a three-component reaction using CuCl/AuCl as sequential catalysts

    K. Jiang, J. Kang, Y. Jin and J. Lin, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00637C

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