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Transition-metal-free radical tri-/difluoromethylation of N,N-dialkylhydrazones with sodium sulfinates

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Abstract

A novel protocol is herein described for the preparation of tri-/difluoromethylated N,N-dialkylhydrazones under transition-metal-free conditions and this reaction can be scaled up to the gram level easily. The reaction protocol is operationally simple and performed at ambient temperature, allowing obtaining the desired products in satisfactory yields. The easy-to-handle sodium tri- and difluoromethanesulfinates serve as effective fluoroalkyl radical precursors.

Graphical abstract: Transition-metal-free radical tri-/difluoromethylation of N,N-dialkylhydrazones with sodium sulfinates

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Publication details

The article was received on 25 Jul 2017, accepted on 23 Aug 2017 and first published on 24 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QO00635G
Citation: Org. Chem. Front., 2017, Advance Article
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    Transition-metal-free radical tri-/difluoromethylation of N,N-dialkylhydrazones with sodium sulfinates

    X. Xu and F. Liu, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00635G

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