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Highly efficient and versatile synthesis of α,α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes

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Abstract

A novel method for the synthesis of α,α-difluoro-γ-lactam derivatives has been developed using a copper/amine catalyst via a tandem radical cyclization pathway. This protocol provides a convenient and straightforward strategy for the rapid construction of various 3,3-difluoro-γ-lactam moieties from easily available alkenes and N-aryl bromodifluoroacetamide as starting materials under mild reaction conditions.

Graphical abstract: Highly efficient and versatile synthesis of α,α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes

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Publication details

The article was received on 21 Jul 2017, accepted on 01 Sep 2017 and first published on 04 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00611J
Citation: Org. Chem. Front., 2017, Advance Article
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    Highly efficient and versatile synthesis of α,α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes

    H. Chen, X. Wang, M. Guo, W. Zhao, X. Tang and G. Wang, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00611J

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