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Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

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Abstract

Mycolactone A/B, a complex polyketidic macrolide secreted by Mycobacterium ulcerans, has been synthesized using catalytic and/or asymmetric reactions. Several palladium-catalyzed reactions were investigated for forging key σ-bonds as well as a particularly challenging hydroboration reaction of a functionalized and sterically demanding 1,1-disubstituted exo-alkene. The full account of these investigations is discussed.

Graphical abstract: Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

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Publication details

The article was received on 20 Jul 2017, accepted on 25 Aug 2017 and first published on 28 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QO00608J
Citation: Org. Chem. Front., 2017, Advance Article
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    Synthetic strategies towards mycolactone A/B, an exotoxin secreted by Mycobacterium ulcerans

    S. Saint-Auret, H. Abdelkafi, D. Le Nouen, P. Bisseret and N. Blanchard, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00608J

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