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NHC-catalyzed enantioselective synthesis of dihydropyran-4-carbonitriles bearing all-carbon quaternary centers

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Abstract

A carbene-catalyzed oxidative reaction for the synthesis of dihydropyran-4-carbonitriles bearing all-carbon quaternary centers was developed. The use of a LiCl additive significantly improved both the reaction efficiency and stereo-selectivities, and the carbonitrile products were obtained in good yields and excellent er values.

Graphical abstract: NHC-catalyzed enantioselective synthesis of dihydropyran-4-carbonitriles bearing all-carbon quaternary centers

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Publication details

The article was received on 10 Jul 2017, accepted on 23 Aug 2017 and first published on 24 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QO00571G
Citation: Org. Chem. Front., 2017, Advance Article
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    NHC-catalyzed enantioselective synthesis of dihydropyran-4-carbonitriles bearing all-carbon quaternary centers

    Q. Wu, C. Li, W. Wang, H. Wang, D. Pan and P. Zheng, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00571G

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