Jump to main content
Jump to site search


Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines

Author affiliations

Abstract

A highly enantioselective Rh-catalyzed addition of arylboronic acids to non-benzofused five-membered cyclic N-sulfonyl alkyl-substituted ketimines has been developed. With simple chiral sulfur-olefin as the ligand, the reaction allows convenient access to a variety of sulfamidates with uniformly excellent enantioselectivities (97–99% ee). The synthetic utility of this protocol was exemplified by rapid asymmetric construction of tetrasubstituted chiral β-amino alcohols and their derivatives.

Graphical abstract: Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines

Back to tab navigation

Supplementary files

Publication details

The article was received on 06 Jul 2017, accepted on 02 Aug 2017 and first published on 03 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QO00555E
Citation: Org. Chem. Front., 2017, Advance Article
  •   Request permissions

    Highly enantioselective Rh/chiral sulfur-olefin-catalyzed arylation of alkyl-substituted non-benzofused cyclic N-sulfonyl ketimines

    M. Liu, T. Jiang, W. Chen and M. Xu, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00555E

Search articles by author

Spotlight

Advertisements