Jump to main content
Jump to site search

Issue 11, 2017
Previous Article Next Article

Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

Author affiliations

Abstract

A tandem radical cyclization reaction towards the 6/6/5 fused tricyclic skeleton, which exists in numerous natural products, was developed in modest to good yields. In this transformation, two C–C bonds and two rings were formed successively via a tandem 5-exo-trig/6-endo-trig cyclization reaction. 5-epi-7-deoxy-Isoabietenin A was also synthesized efficiently via this strategy.

Graphical abstract: Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

Back to tab navigation

Supplementary files

Publication details

The article was received on 04 Jul 2017, accepted on 14 Aug 2017 and first published on 15 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QO00550D
Citation: Org. Chem. Front., 2017,4, 2211-2215
  •   Request permissions

    Rapid construction of the 6/6/5 tricyclic framework via a tandem radical cyclization reaction and its application to the synthesis of 5-epi-7-deoxy-isoabietenin A

    H. Zhang, S. Ma, Z. Xing, L. Liu, B. Fang, X. Xie and X. She, Org. Chem. Front., 2017, 4, 2211
    DOI: 10.1039/C7QO00550D

Search articles by author

Spotlight

Advertisements