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Facile synthesis of 1-aminoindoles via Rh(III)-catalysed intramolecular three-component annulation

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Abstract

The facile synthesis of various 1-aminoindoles from readily available aryl hydrazines, diazo compounds and ketones via rhodium catalysed C–H activation has been developed. The reaction was carried out under mild reaction conditions using hydrazone as a directing group, which was formed by the in situ condensation of hydrazines and ketones. This protocol exhibits a broad substrate scope and step economy, releasing N2 and H2O as the byproducts, obviating the need for external oxidants and pre-functionalized substrates.

Graphical abstract: Facile synthesis of 1-aminoindoles via Rh(iii)-catalysed intramolecular three-component annulation

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Publication details

The article was received on 01 Jul 2017, accepted on 02 Aug 2017 and first published on 07 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QO00541E
Citation: Org. Chem. Front., 2017, Advance Article
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    Facile synthesis of 1-aminoindoles via Rh(III)-catalysed intramolecular three-component annulation

    Z. Yang, X. Lin, L. Wang and X. Cui, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00541E

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