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Issue 11, 2017
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Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

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Abstract

A transition-metal-free synthetic approach to synthesize indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed. A variety of functional groups were tolerated under mild reaction conditions. Moreover, Michael addition, intramolecular N-alkylation and aromatization were involved in this convergent and feasible “one-pot” tandem reaction to afford the annulation products in moderate to good yields.

Graphical abstract: Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

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Publication details

The article was received on 29 Jun 2017, accepted on 19 Jul 2017 and first published on 21 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00529F
Citation: Org. Chem. Front., 2017,4, 2119-2123
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    Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

    Y. Liu, Y. Yu, Y. Fu, Y. Liu, L. Shi, H. Li and W. Wang, Org. Chem. Front., 2017, 4, 2119
    DOI: 10.1039/C7QO00529F

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