Jump to main content
Jump to site search

Issue 11, 2017
Previous Article Next Article

Diastereoselective building up polycyclic tetrahydrofurans via tandem annulation of 1,n-enynes with aliphatic acids

Author affiliations

Abstract

A silver-catalyzed tandem annulation of aniline-linked 1,7-enynes with aliphatic acids has been reported. This synergistic tandem annulations allow the straightforward and efficient building up various highly diastereoselective polycyclic tetrahydrofurans. Primary and secondary acids undergo decarboxylation/cascade radical addition/α-C(sp3)–H cleavage/cycloalkylation/O-trapping to generate oxygenous [6.6.6.5] fused products. While tertiary acids undergo decarboxylation/cascade radcial addition/β-C(sp3)–H cleavage/O-trapping to give oxygenous [6.6.6.6] fused products.

Graphical abstract: Diastereoselective building up polycyclic tetrahydrofurans via tandem annulation of 1,n-enynes with aliphatic acids

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jun 2017, accepted on 24 Jul 2017 and first published on 24 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00527J
Citation: Org. Chem. Front., 2017,4, 2147-2152
  •   Request permissions

    Diastereoselective building up polycyclic tetrahydrofurans via tandem annulation of 1,n-enynes with aliphatic acids

    L. Lv, S. Lu, Y. Chen and Z. Li, Org. Chem. Front., 2017, 4, 2147
    DOI: 10.1039/C7QO00527J

Search articles by author

Spotlight

Advertisements