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Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization

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Abstract

A novel method for the synthesis of multisubstituted oxazoles by palladium-catalyzed oxidative cyclization of N-acyl enamides has been developed. The reaction employs readily available iodobenzenes and enamides as the starting materials under mild reaction conditions and provides a reliable way to achieve versatile substituted oxazole derivatives.

Graphical abstract: Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization

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Publication details

The article was received on 26 Jun 2017, accepted on 28 Aug 2017 and first published on 04 Sep 2017


Article type: Research Article
DOI: 10.1039/C7QO00517B
Citation: Org. Chem. Front., 2017, Advance Article
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    Synthesis of substituted oxazoles via Pd-catalyzed tandem oxidative cyclization

    W. Zhang, W. Yu, Q. Yan, Z. Liu and Y. Zhang, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00517B

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