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Multifunctional odorless isocyano(triphenylphosphoranylidene)-acetates: synthesis and direct one-pot four-component Ugi/Wittig cyclization to multisubstituted oxazoles

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Abstract

The multifunctional odorless isocyano(triphenylphosphorany-lidene)acetate was prepared as a new stable phosphorus ylide containing isocyanide group. A new one-pot four component synthesis of multisubstituted oxazoles by a cascade Ugi/Wittig process without Mumm rearrangement has been developed, starting from the isocyano(triphenylphosphora-nylidene)acetates, aldehydes, amines and acids. Two component reactions of isocyano(triphenylphosphoranylidene)-acetates and acids also generated disubstituted oxazoles in good yields.

Graphical abstract: Multifunctional odorless isocyano(triphenylphosphoranylidene)-acetates: synthesis and direct one-pot four-component Ugi/Wittig cyclization to multisubstituted oxazoles

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Publication details

The article was received on 20 Jun 2017, accepted on 16 Jul 2017 and first published on 17 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00490G
Citation: Org. Chem. Front., 2017, Advance Article
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    Multifunctional odorless isocyano(triphenylphosphoranylidene)-acetates: synthesis and direct one-pot four-component Ugi/Wittig cyclization to multisubstituted oxazoles

    Z. Ren, Z. Guan, H. Kong and M. Ding, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00490G

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