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Copper-catalyzed radical 1,2-cyclization of indoles with arylsulfonyl hydrazides: access to 2-thiolated 3H-pyrrolo[1,2-a]indoles

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Abstract

A copper-catalyzed cascade radical 1,2-cyclization of indoles with arylsulfonyl hydrazides was developed, affording a series of 2-thiolated 3H-pyrrolo[1,2-a]indoles in moderate to excellent yields. This transformation proceeded with sequential radical addition to a triple bond and a cyclization procedure, where arylsulfonyl hydrazides served as thioarylation reagents.

Graphical abstract: Copper-catalyzed radical 1,2-cyclization of indoles with arylsulfonyl hydrazides: access to 2-thiolated 3H-pyrrolo[1,2-a]indoles

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Publication details

The article was received on 17 Jun 2017, accepted on 27 Jul 2017 and first published on 31 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00478H
Citation: Org. Chem. Front., 2017, Advance Article
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    Copper-catalyzed radical 1,2-cyclization of indoles with arylsulfonyl hydrazides: access to 2-thiolated 3H-pyrrolo[1,2-a]indoles

    J. Zhu, S. Sun, M. Xia, N. Gu and J. Cheng, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00478H

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