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Phosphinodifluoroalkylation of alkynes using P(O)H compounds and ethyl difluoroiodoacetate

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Abstract

The first phosphinodifluoroalkylation of alkynes is achieved and the simultaneous addition of both difluoromethylene and phosphinoyl groups across the alkynes with high regio- and stereoselectivity is of great significance. By using palladium(II) chloride as a catalyst and Xantphos as a ligand, the reaction of P(O)H compounds, alkynes, and ethyl difluoroiodoacetate proceeds with moderate to high yields, and provides an attractive approach for the construction of (E)-γ,γ-difluoroalkenylphosphine oxides.

Graphical abstract: Phosphinodifluoroalkylation of alkynes using P(O)H compounds and ethyl difluoroiodoacetate

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Publication details

The article was received on 13 Jun 2017, accepted on 14 Jul 2017 and first published on 17 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00466D
Citation: Org. Chem. Front., 2017, Advance Article
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    Phosphinodifluoroalkylation of alkynes using P(O)H compounds and ethyl difluoroiodoacetate

    P. Zhang, J. Ying, G. Tang and Y. Zhao, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00466D

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