Jump to main content
Jump to site search

Issue 11, 2017
Previous Article Next Article

Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source

Author affiliations

Abstract

A convenient method mediated by photoredox catalysis for the direct construction of 1,4-dicarbonyl compounds has been developed. Simple aromatic symmetric carboxylic anhydrides or mixed anhydrides (generated in situ) have been utilized as an acyl radical source in addition to different types of Michael acceptors. A wide range of substrates are amenable to this new type of acyl Michael addition under mild conditions with broad functional group tolerance. As an application, a novel four-step synthesis of medicinal agent haloperidol is also presented.

Graphical abstract: Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Jun 2017, accepted on 22 Jul 2017 and first published on 02 Aug 2017


Article type: Research Article
DOI: 10.1039/C7QO00453B
Citation: Org. Chem. Front., 2017,4, 2230-2234
  •   Request permissions

    Visible-light photoredox catalyzed hydroacylation of electron-deficient alkenes: carboxylic anhydride as an acyl radical source

    S. Dong, G. Wu, X. Yuan, C. Zou and J. Ye, Org. Chem. Front., 2017, 4, 2230
    DOI: 10.1039/C7QO00453B

Search articles by author

Spotlight

Advertisements