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meta-Selective C-H Difluoromethylation of Various Arenes with a Versatile Ruthenium Catalyst

Abstract

A ruthenium-enabled meta-selective C-H difluoromethylation of arenes has been developed. Various arenes bearing pyridyl, pyrazolyl, imidazolyl, or pyrimidyl directing groups, or removable oxazoline directing groups, were tolerated in this meta-selective C-H difluoromethtylation, affording the difluoromethylated products in moderate to good yields. The difluoromethtyl group could be selectively installed into several drug molecules and bioactive compounds in one step, highlighting the synthetic utility and importance of this new method.

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Publication details

The article was received on 07 Jun 2017, accepted on 17 Jun 2017 and first published on 19 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00449D
Citation: Org. Chem. Front., 2017, Accepted Manuscript
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    meta-Selective C-H Difluoromethylation of Various Arenes with a Versatile Ruthenium Catalyst

    C. Yuan, X. Chen, J. Zhang and Y. Zhao, Org. Chem. Front., 2017, Accepted Manuscript , DOI: 10.1039/C7QO00449D

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