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Issue 10, 2017
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Highly stereoselective synthesis and application of P-chiral ferrocenyl bisphosphorus ligands for asymmetric hydrogenation

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Abstract

New, efficient and highly stereoselective methods were developed for the synthesis/modification of Wudaphos type ligands. It was found that the “three hindered quadrant” model is crucial to ensure high enantiomeric control and that the substituents on the phosphine atom should be electron rich to increase the reactivity. Moreover, a new SPO-Wudaphos ligand was developed, which exhibited good to excellent enantioselectivities in the asymmetric hydrogenation of α-methylene-γ-keto carboxylic acids.

Graphical abstract: Highly stereoselective synthesis and application of P-chiral ferrocenyl bisphosphorus ligands for asymmetric hydrogenation

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Publication details

The article was received on 07 Jun 2017, accepted on 07 Jul 2017 and first published on 10 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00448F
Citation: Org. Chem. Front., 2017,4, 2034-2038
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    Highly stereoselective synthesis and application of P-chiral ferrocenyl bisphosphorus ligands for asymmetric hydrogenation

    C. Chen, S. Wen, X. Dong and X. Zhang, Org. Chem. Front., 2017, 4, 2034
    DOI: 10.1039/C7QO00448F

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