Jump to main content
Jump to site search

Issue 10, 2017
Previous Article Next Article

Palladium-catalyzed site-selective direct olefination of 6-electron-withdrawing group substituted 3-arylbenzo[d]isoxazoles

Author affiliations

Abstract

A palladium-catalyzed direct olefination of 6-electron-withdrawing group substituted 3-arylbenzo[d]isoxazoles has been developed with exclusive site-selectivity and excellent E-stereoselectivity. It was found that the olefination occurred at the acidic C-7 position only, overriding a potential directing-group assisted bias. With the wide range of alkene patterns, the protocol allows convenient access to multifarious C-7 olefinated benzo[d]isoxazoles in moderate to good yields.

Graphical abstract: Palladium-catalyzed site-selective direct olefination of 6-electron-withdrawing group substituted 3-arylbenzo[d]isoxazoles

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 Jun 2017, accepted on 26 Jun 2017 and first published on 27 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00435D
Citation: Org. Chem. Front., 2017,4, 1962-1966
  •   Request permissions

    Palladium-catalyzed site-selective direct olefination of 6-electron-withdrawing group substituted 3-arylbenzo[d]isoxazoles

    Y. Guo, L. Shao, K. Yu, Y. Hu, H. Liu, D. Liao and Y. Ji, Org. Chem. Front., 2017, 4, 1962
    DOI: 10.1039/C7QO00435D

Search articles by author

Spotlight

Advertisements