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Issue 11, 2017
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Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

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Abstract

It still remains a major challenge to apply free primary amino groups as the directing group for aliphatic C–H functionalization. In this article, we used the protonation strategy to control the binding ability of primary amines and realized free amino group directed inert aliphatic C–H acetoxylation in good chemo- and regio-selectivity. This methodology provided a straightforward approach from primary amines to γ-amino alcohols.

Graphical abstract: Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

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Publication details

The article was received on 13 Jun 2017, accepted on 17 Jul 2017 and first published on 27 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00432J
Citation: Org. Chem. Front., 2017,4, 2097-2101
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    Palladium catalyzed C(sp3)–H acetoxylation of aliphatic primary amines to γ-amino alcohol derivatives

    K. Chen, D. Wang, Z. Li, Z. Liu, F. Pan, Y. Zhang and Z. Shi, Org. Chem. Front., 2017, 4, 2097
    DOI: 10.1039/C7QO00432J

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