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Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na

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Abstract

An efficient copper(I)-catalyzed trifluoromethylation of styrene derivatives using CF3SO2Na as a trifluoromethylating source in the presence of tBuOOtBu has been developed. Mechanistic studies show that the reaction likely proceeds via a radical pathway, providing a general and straightforward access to trifluoromethylated styrene derivatives. Advantageously, excellent stereoselectivity is obtained with styrene derivatives in this transformation.

Graphical abstract: Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na

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Publication details

The article was received on 26 May 2017, accepted on 19 Jun 2017 and first published on 20 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00416H
Citation: Org. Chem. Front., 2017, Advance Article
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    Copper-catalyzed trifluoromethylation of styrene derivatives with CF3SO2Na

    L. Wu, K. Zhao, Z. Shen and T. Loh, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00416H

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