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Issue 10, 2017
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The asymmetric synthesis of multisubstituted diquinanes via the domino reaction of electron-deficient enynes

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Abstract

A N,N′-dioxide/Y(III) complex catalyzed highly enantioselective domino reaction between electron-deficient enynes and a malonate-derived α,β-unsaturated ester was described. A range of multisubstituted diquinanes were obtained in good yields with excellent ee values (91–98% ee). Moreover, the products could be easily transformed into various chiral [3.3.0]bicycle compounds, which were important skeletons of many biologically active compounds and pharmacologicals.

Graphical abstract: The asymmetric synthesis of multisubstituted diquinanes via the domino reaction of electron-deficient enynes

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Publication details

The article was received on 23 May 2017, accepted on 04 Jul 2017 and first published on 05 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00408G
Citation: Org. Chem. Front., 2017,4, 2012-2015
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    The asymmetric synthesis of multisubstituted diquinanes via the domino reaction of electron-deficient enynes

    Q. Yao, L. Lin, H. Zhang, H. Yu, Q. Xiong, X. Liu and X. Feng, Org. Chem. Front., 2017, 4, 2012
    DOI: 10.1039/C7QO00408G

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