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Issue 10, 2017
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A one-pot, metal-free approach to bicyclic 2-pyridones

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Abstract

A one-pot, metal-free approach for the synthesis of 3,4-disubstituted, bicyclic 2-pyridones was developed. The reaction occurred through the intramolecular, two-fold sequential cyclization of Michael adducts under thermal basic conditions. The methodology proceeded with a range of substrates to afford bicyclic 2-pyridones in up to 85% yield, and provided direct and easy access to two Tylophora alkaloid core structures.

Graphical abstract: A one-pot, metal-free approach to bicyclic 2-pyridones

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Publication details

The article was received on 23 May 2017, accepted on 02 Jul 2017 and first published on 03 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00406K
Citation: Org. Chem. Front., 2017,4, 2026-2030
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    A one-pot, metal-free approach to bicyclic 2-pyridones

    S. Ruchirawat and W. Disadee, Org. Chem. Front., 2017, 4, 2026
    DOI: 10.1039/C7QO00406K

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