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Issue 9, 2017
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Silver-catalyzed cyclization of nitrones with 2-azetine: a radical approach to 2,3-disubstituted quinolines

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Abstract

A silver-catalyzed intermolecular tandem cyclization of nitrones with 2-azetine was developed for the synthesis of 2,3-disubstituted quinolines under mild conditions with good yields. This approach features a C–N bond cleavage of 2-azetine and an N–O bond cleavage of nitrones via a radical pathway. The results of this study provide a new reaction pattern for nitrones and may find applications in the synthesis of other heterocycles.

Graphical abstract: Silver-catalyzed cyclization of nitrones with 2-azetine: a radical approach to 2,3-disubstituted quinolines

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Publication details

The article was received on 23 May 2017, accepted on 12 Jun 2017 and first published on 12 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00405B
Citation: Org. Chem. Front., 2017,4, 1833-1838
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    Silver-catalyzed cyclization of nitrones with 2-azetine: a radical approach to 2,3-disubstituted quinolines

    H. Yan, X. Li, C. Wang and B. Wan, Org. Chem. Front., 2017, 4, 1833
    DOI: 10.1039/C7QO00405B

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