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Issue 10, 2017
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Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

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Abstract

The highly efficient direct catalytic reductive amination of aromatic ketones with diphenylmethanamine is described. Catalyzed by the iridium–monodentate phosphoramidite complex and assisted using additives, this concise and practical route provided chiral amines in high yields and with high enantioselectivity (ee values of up to 99%).

Graphical abstract: Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

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Publication details

The article was received on 21 May 2017, accepted on 27 Jun 2017 and first published on 28 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00400A
Citation: Org. Chem. Front., 2017,4, 1976-1980
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    Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

    H. Huang, Z. Wu, G. Gao, L. Zhou and M. Chang, Org. Chem. Front., 2017, 4, 1976
    DOI: 10.1039/C7QO00400A

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