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Issue 10, 2017
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Efficient synthesis of 2-substituted azoles: radical C–H alkylation of azoles with dicumyl peroxide, methylarenes and cycloalkanes under metal-free condition

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Abstract

A simple and efficient synthesis of 2-substituted azoles by alkylation of azoles with dicumyl peroxide, methylarenes and cycloalkanes under metal-free condition has been developed. The transformation can proceed smoothly in the presence of tert-butyl peroxide (DTBP) as an oxidant and dicumyl peroxide (DCP) as a methylation reagent with wide substrate scope and good yields. Mechanistic details including radical reaction process are also described.

Graphical abstract: Efficient synthesis of 2-substituted azoles: radical C–H alkylation of azoles with dicumyl peroxide, methylarenes and cycloalkanes under metal-free condition

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Publication details

The article was received on 20 May 2017, accepted on 04 Jul 2017 and first published on 05 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00396J
Citation: Org. Chem. Front., 2017,4, 2039-2043
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    Efficient synthesis of 2-substituted azoles: radical C–H alkylation of azoles with dicumyl peroxide, methylarenes and cycloalkanes under metal-free condition

    Z. Li, L. Jin and C. Cai, Org. Chem. Front., 2017, 4, 2039
    DOI: 10.1039/C7QO00396J

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