Jump to main content
Jump to site search

Issue 10, 2017
Previous Article Next Article

An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582

Author affiliations

Abstract

Control over the C-20 stereochemistry allows a versatile method to introduce novel side-chains into the vitamin D scaffold. Using our building blocks containing stereodefined stereochemistry at C-20 we demonstrated that we could improve the current synthesis of calcitriol analogs with potentially interesting biological properties.

Graphical abstract: An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582

Back to tab navigation

Supplementary files

Publication details

The article was received on 16 May 2017, accepted on 02 Jul 2017 and first published on 03 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00381A
Citation: Org. Chem. Front., 2017,4, 1999-2001
  •   Request permissions

    An improved methodology for the synthesis of 1α,25-dihydroxy-20-epi-vitamin D3 (MC 1288) and Gemini analog Ro-438-3582

    H. Santalla, A. Martínez, F. Garrido, G. Gómez and Y. Fall, Org. Chem. Front., 2017, 4, 1999
    DOI: 10.1039/C7QO00381A

Search articles by author

Spotlight

Advertisements