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Issue 9, 2017
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Palladium-catalyzed C(sp2)–H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles

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Abstract

An efficient access to amino substituted phenanthridine and isoquinoline derivatives, through palladium-catalyzed C(sp2)–H aminoimidoylation, has been developed. This process applies O-benzoyl hydroxylamines as oxidative amino sources to generate amino Pd(II) intermediates, followed by isocyanide insertion and intramolecular C(sp2)–H activation. Sequential C–N and C–C bond formation took place on isocyano-containing arenes in one step.

Graphical abstract: Palladium-catalyzed C(sp2)–H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles

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Publication details

The article was received on 10 May 2017, accepted on 02 Jun 2017 and first published on 06 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00368D
Citation: Org. Chem. Front., 2017,4, 1768-1771
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    Palladium-catalyzed C(sp2)–H aminoimidoylation of isocyano-containing arenes: synthesis of amino substituted N-heterocycles

    Z. Xiong, J. Wang, Y. Wang, S. Luo and Q. Zhu, Org. Chem. Front., 2017, 4, 1768
    DOI: 10.1039/C7QO00368D

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