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Issue 10, 2017
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Copper(II) catalyzed domino synthesis of quinoline derivatives from arylamines and alkynes

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Abstract

The Cu(OAc)2·H2O catalyzed domino reaction of primary arylamines and electron-deficient terminal alkynes was developed at room temperature. It provides a convenient access to a variety of 2,4-disubstituted quinolines in good to excellent yields without protection from moisture or air. Control experiments suggest that the reaction might be initiated from alkyne homocoupling, followed by copper catalyzed hydroamination and cyclization.

Graphical abstract: Copper(ii) catalyzed domino synthesis of quinoline derivatives from arylamines and alkynes

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Publication details

The article was received on 27 Apr 2017, accepted on 03 Jul 2017 and first published on 04 Jul 2017


Article type: Research Article
DOI: 10.1039/C7QO00333A
Citation: Org. Chem. Front., 2017,4, 2008-2011
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    Copper(II) catalyzed domino synthesis of quinoline derivatives from arylamines and alkynes

    H. Dai, C. Li, C. Yu, Z. Wang, H. Yan and C. Lu, Org. Chem. Front., 2017, 4, 2008
    DOI: 10.1039/C7QO00333A

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