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Palladium-catalyzed direct ortho-alkynylation of arylalkylacid derivatives at γ and δ positions via an N,O-bidentate directing group

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Abstract

Palladium-catalyzed ortho-alkynylation of arylalkylacid derivatives at remote γ and δ positions with the assistance of an N,O-bidentate directing group of glycine dimethylamide (GDMA) is reported for the first time. A wide variety of phenylacetic acid and 3-phenylpropionic acid derivatives is tolerated in this protocol, which provides a general means to synthesize substituted alkynylarylalkyl acid derivatives.

Graphical abstract: Palladium-catalyzed direct ortho-alkynylation of arylalkylacid derivatives at γ and δ positions via an N,O-bidentate directing group

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Publication details

The article was received on 25 Apr 2017, accepted on 21 Jun 2017 and first published on 23 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00327G
Citation: Org. Chem. Front., 2017, Advance Article
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    Palladium-catalyzed direct ortho-alkynylation of arylalkylacid derivatives at γ and δ positions via an N,O-bidentate directing group

    G. Li, P. Liu, J. Zhang, D. Shi and Y. Zhao, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00327G

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