Palladium-catalyzed direct ortho-alkynylation of arylalkylacid derivatives at γ and δ positions via an N,O-bidentate directing group

Abstract

Palladium-catalyzed ortho-alkynylation of arylalkylacid derivatives at remote γ and δ positions with the assistance of an N,O-bidentate directing group of glycine dimethylamide (GDMA) is reported for the first time. A wide variety of phenylacetic acid and 3-phenylpropionic acid derivatives is tolerated in this protocol, which provides a general means to synthesize substituted alkynylarylalkyl acid derivatives.