Issue 9, 2017

Metal-free phosphonation of benzoxazoles and benzothiazoles under oxidative conditions

Abstract

An iodine promoted phosphonation of benzoxazoles and benzothiazoles with trialkyl phosphites was described. This reaction undergoes three steps: an addition procedure, followed by a radical oxidation, and an elimination reaction, provides an efficient method to access 2-phosphated products with a broad scope of substrates.

Graphical abstract: Metal-free phosphonation of benzoxazoles and benzothiazoles under oxidative conditions

Supplementary files

Article information

Article type
Research Article
Submitted
23 Apr 2017
Accepted
02 Jun 2017
First published
05 Jun 2017

Org. Chem. Front., 2017,4, 1781-1784

Metal-free phosphonation of benzoxazoles and benzothiazoles under oxidative conditions

J. Gong, L. Huang, Q. Deng, K. Jie, Y. Wang, S. Guo and H. Cai, Org. Chem. Front., 2017, 4, 1781 DOI: 10.1039/C7QO00318H

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