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Issue 8, 2017
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Ir/BiphPHOX-catalyzed asymmetric hydrogenation of 3-substituted 2,5-dihydropyrroles and 2,5-dihydrothiophene 1,1-dioxides

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Abstract

An efficient asymmetric hydrogenation of 3-substituted 2,5-dihydropyrroles using an Ir catalyst with an axially flexible chiral phosphine-oxazoline ligand was developed and chiral 3-substituted pyrrolidines could be prepared with excellent ee. 3-Substituted 2,5-dihydrothiophene 1,1-dioxides could also be hydrogenated by our catalyst, giving the desired products with moderate to high enantioselectivities.

Graphical abstract: Ir/BiphPHOX-catalyzed asymmetric hydrogenation of 3-substituted 2,5-dihydropyrroles and 2,5-dihydrothiophene 1,1-dioxides

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Publication details

The article was received on 30 Mar 2017, accepted on 10 May 2017 and first published on 11 May 2017


Article type: Research Article
DOI: 10.1039/C7QO00248C
Citation: Org. Chem. Front., 2017,4, 1601-1605
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    Ir/BiphPHOX-catalyzed asymmetric hydrogenation of 3-substituted 2,5-dihydropyrroles and 2,5-dihydrothiophene 1,1-dioxides

    K. Meng, J. Xia, Y. Wang, X. Zhang, G. Yang and W. Zhang, Org. Chem. Front., 2017, 4, 1601
    DOI: 10.1039/C7QO00248C

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