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Pd-Catalyzed thiophene directed regioselective functionalization of arenes: a direct approach to multiply-substituted benzyl amines

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Abstract

The first example of employing thiophene as the coordination center to assist C–H functionalization via a palladium catalyst has been described. The synthetically challenging penta-substituted benzylamines with five different functional groups could be easily achieved by taking advantage of transitive oxalyl amide/thiophene-directed C–H functionalization, which highlights its versatility in the construction of multiply-substituted arenes. The penta-substituted benzylamine displays its potential nature as a hole-transporting material.

Graphical abstract: Pd-Catalyzed thiophene directed regioselective functionalization of arenes: a direct approach to multiply-substituted benzyl amines

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Publication details

The article was received on 25 Mar 2017, accepted on 22 Apr 2017 and first published on 28 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00236J
Citation: Org. Chem. Front., 2017, Advance Article
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    Pd-Catalyzed thiophene directed regioselective functionalization of arenes: a direct approach to multiply-substituted benzyl amines

    J. Hu, G. Li, Z. Huang, J. Zhang, D. Shi and Y. Zhao, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00236J

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