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Palladium-catalyzed C–S bond activation and functionalization of 3-sulfenylindoles and related electron-rich heteroarenes

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Abstract

A novel and efficient palladium-catalyzed approach for copper-mediated C–S bond activation and functionalization of 3-sulfenylheteroarenes has been established. This protocol features good functional group compatibility and a broad substrate scope, and can serve as a powerful synthetic tool for the construction and late-stage modification of important heteroarene scaffolds. Remarkably, both the N-protected and free N–H indoles were nicely suitable for this transformation.

Graphical abstract: Palladium-catalyzed C–S bond activation and functionalization of 3-sulfenylindoles and related electron-rich heteroarenes

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Publication details

The article was received on 17 Mar 2017, accepted on 09 May 2017 and first published on 10 May 2017


Article type: Research Article
DOI: 10.1039/C7QO00215G
Citation: Org. Chem. Front., 2017, Advance Article
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    Palladium-catalyzed C–S bond activation and functionalization of 3-sulfenylindoles and related electron-rich heteroarenes

    J. Li, Y. An, J. Li, S. Yang, W. Wu and H. Jiang, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00215G

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