Palladium-catalyzed C–S bond activation and functionalization of 3-sulfenylindoles and related electron-rich heteroarenes

Abstract

A novel and efficient palladium-catalyzed approach for copper-mediated C–S bond activation and functionalization of 3-sulfenylheteroarenes has been established. This protocol features good functional group compatibility and a broad substrate scope, and can serve as a powerful synthetic tool for the construction and late-stage modification of important heteroarene scaffolds. Remarkably, both the N-protected and free N–H indoles were nicely suitable for this transformation.