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Intramolecular aminocyanation of alkenes promoted by hypervalent iodine

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Abstract

A transition metal-free and hypervalent iodine-promoted annulative aminocyanation of unactivated alkenes has been developed for the first time. This regioselective 5-exo-trig process provides a concise method to synthesize diversely substituted cyanated pyrrolidine, piperidine and indoline derivatives under mild reaction conditions with up to 80% yield, in which the cyanated position of the double bond is controlled by different hypervalent iodine regents.

Graphical abstract: Intramolecular aminocyanation of alkenes promoted by hypervalent iodine

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Publication details

The article was received on 16 Mar 2017, accepted on 07 Jun 2017 and first published on 12 Jun 2017


Article type: Research Article
DOI: 10.1039/C7QO00214A
Citation: Org. Chem. Front., 2017, Advance Article
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    Intramolecular aminocyanation of alkenes promoted by hypervalent iodine

    H. Shen, Q. Deng, R. Liu, Y. Feng, C. Zheng and Y. Xiong, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00214A

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