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Nickel-catalyzed selective C-5 fluorination of 8-aminoquinolines with NFSI

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Abstract

The first nickel-catalyzed C–H selective fluorination of 8-aminoquinoline derivatives at the C-5 position was achieved using NFSI (N-fluorobenzenesulfonimide) as the “F” source and NiSO4 as the catalyst. This method demonstrated broad substrate tolerance under mild conditions and a plausible SET (single electron transfer) mechanism was suggested in the proposal of a radical process.

Graphical abstract: Nickel-catalyzed selective C-5 fluorination of 8-aminoquinolines with NFSI

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Publication details

The article was received on 16 Mar 2017, accepted on 22 Apr 2017 and first published on 02 May 2017


Article type: Research Article
DOI: 10.1039/C7QO00211D
Citation: Org. Chem. Front., 2017, Advance Article
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    Nickel-catalyzed selective C-5 fluorination of 8-aminoquinolines with NFSI

    J. Ding, Y. Zhang and J. Li, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00211D

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