Jump to main content
Jump to site search

Issue 8, 2017
Previous Article Next Article

CuBr-mediated radical cascade difluoroacetamidation of acrylamides using α,α-difluoro-α-(TMS)-acetamides

Author affiliations

Abstract

Radical cascade difluoroacetamidation of N-(arylsulfonyl)acrylamides with α,α-difluoro-α-(TMS)-acetamides has been achieved for the first time. This CuBr-mediated transformation is easy to perform, generates high yields and shows a good substrate scope. This cascade reaction proceeds via difluoroacetamidation, aryl migration and desulfonylation. The products can be readily transformed into synthetically useful compounds such as difluorofunctionalized esters and alcohols in excellent yields.

Graphical abstract: CuBr-mediated radical cascade difluoroacetamidation of acrylamides using α,α-difluoro-α-(TMS)-acetamides

Back to tab navigation

Supplementary files

Publication details

The article was received on 15 Mar 2017, accepted on 03 May 2017 and first published on 08 May 2017


Article type: Research Article
DOI: 10.1039/C7QO00209B
Citation: Org. Chem. Front., 2017,4, 1606-1610
  •   Request permissions

    CuBr-mediated radical cascade difluoroacetamidation of acrylamides using α,α-difluoro-α-(TMS)-acetamides

    K. Liu, L. Sui, Q. Jin, D. Li and P. Liu, Org. Chem. Front., 2017, 4, 1606
    DOI: 10.1039/C7QO00209B

Search articles by author

Spotlight

Advertisements