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Copper-catalyzed aerobic oxidative coupling of ketones with P(O)–H compounds leading to β-ketophosphine oxides

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Abstract

A facile and efficient copper-catalyzed one-pot method for the construction of β-ketophosphine oxides has been developed via aerobic oxidative coupling of various ketones with P(O)–H compounds assisted by TBSOTf (t-butyldimethylsilyl triflate). Through this methodology, a series of β-ketophosphine oxides can be easily obtained in moderate to good yields with favorable functional group tolerance under very mild conditions. Isotope-labeling experiments suggested that the carbonyl oxygen atom of β-ketophosphine oxides originated from dioxygen.

Graphical abstract: Copper-catalyzed aerobic oxidative coupling of ketones with P(O)–H compounds leading to β-ketophosphine oxides

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Publication details

The article was received on 13 Mar 2017, accepted on 16 Apr 2017 and first published on 17 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00202E
Citation: Org. Chem. Front., 2017, Advance Article
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    Copper-catalyzed aerobic oxidative coupling of ketones with P(O)–H compounds leading to β-ketophosphine oxides

    Q. Fu, D. Yi, Z. Zhang, W. Liang, S. Chen, L. Yang, Q. Zhang, J. Ji and W. Wei, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00202E

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