Jump to main content
Jump to site search


Metal-free chloroamidation of indoles with sulfonamides and NaClO

Author affiliations

Abstract

An efficient and rapid protocol for chloroamidation of indoles with sulfonamides and aqueous NaClO has been developed. The reaction completes in less than half an hour at room temperature without any transition metals. Both indoles and sulfonamides can be easily varied with high functional group tolerance. A variety of structurally diverse 3-chloro-2-amidoindoles are prepared with up to 97% yields.

Graphical abstract: Metal-free chloroamidation of indoles with sulfonamides and NaClO

Back to tab navigation

Supplementary files

Publication details

The article was received on 13 Mar 2017, accepted on 05 Apr 2017 and first published on 06 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00199A
Citation: Org. Chem. Front., 2017, Advance Article
  •   Request permissions

    Metal-free chloroamidation of indoles with sulfonamides and NaClO

    X. Liu, K. Tong, A. H. Zhang, R. X. Tan and S. Yu, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00199A

Search articles by author

Spotlight

Advertisements