Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance upgrade on Thursday 4th of May 2017 from 8.00am to 9.00am (BST).

During this time our websites will be offline temporarily. If you have any questions please use the feedback button on this page. We apologise for any inconvenience this might cause and thank you for your patience.



Direct coupling of sp3 carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system

Author affiliations

Abstract

A new methodology for the monovalent copper-initiated direct coupling of alkanes and hydroperoxides with unsaturated carbonyl compounds is developed. In this work, α,β-unsaturated carbonyl compounds underwent alkylation and peroxidation to give synthetically useful α-peroxy ketones with wide functional group tolerance. The resulting α-peroxy ketones could be easily transformed into very useful α-hydroxy ketones.

Graphical abstract: Direct coupling of sp3 carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 23 Feb 2017, accepted on 27 Mar 2017 and first published on 05 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00149E
Citation: Org. Chem. Front., 2017, Advance Article
  •   Request permissions

    Direct coupling of sp3 carbon of alkanes with α,β-unsaturated carbonyl compounds using a copper/hydroperoxide system

    Y. Lan, C. Yang, Y. Xu and T. Loh, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00149E

Search articles by author