Jump to main content
Jump to site search


Copper-catalyzed oxidative amidation of α,β-unsaturated ketones via selective C–H or C–C bond cleavage

Author affiliations

Abstract

The copper-catalyzed oxidative amidation of readily available α,β-unsaturated ketones with N-fluorobenzenesulfonimide (NFSI) for the synthesis of biologically active enamides or α-amino substituted unsaturated ketone skeletons has been achieved. These transformations processed via a radical pathway, thus the amidation occurred at the unusual α-position of the α,β-unsaturated ketones, leading to the following effective C(CO)–C(vinyl) or C(vinyl)–H bond cleavage with high selectivity.

Graphical abstract: Copper-catalyzed oxidative amidation of α,β-unsaturated ketones via selective C–H or C–C bond cleavage

Back to tab navigation
Please wait while Download options loads

Supplementary files

Publication details

The article was received on 22 Feb 2017, accepted on 22 Apr 2017 and first published on 24 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00146K
Citation: Org. Chem. Front., 2017, Advance Article
  •   Request permissions

    Copper-catalyzed oxidative amidation of α,β-unsaturated ketones via selective C–H or C–C bond cleavage

    T. W. Pouambeka, G. Zhang, G. Zheng, G. Xu, Q. Zhang, T. Xiong and Q. Zhang, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00146K

Search articles by author