Jump to main content
Jump to site search

Issue 7, 2017
Previous Article Next Article

Enantioselective synthesis of a cyclobutane analogue of Milnacipran

Author affiliations

Abstract

The asymmetric synthesis of a cyclobutane analogue of the antidepressant drug Milnacipran is reported. The optically active derivative incorporates a central cyclobutane ring in lieu of the cyclopropane unit classically found in Milnacipran. The two stereogenic centres borne by the cyclobutane were sequentially installed starting from phenylacetonitrile.

Graphical abstract: Enantioselective synthesis of a cyclobutane analogue of Milnacipran

Back to tab navigation

Supplementary files

Publication details

The article was received on 20 Feb 2017, accepted on 23 Mar 2017 and first published on 23 Mar 2017


Article type: Research Article
DOI: 10.1039/C7QO00140A
Citation: Org. Chem. Front., 2017,4, 1276-1280
  •   Request permissions

    Enantioselective synthesis of a cyclobutane analogue of Milnacipran

    D. Nguyen, E. Gravel, D. Buisson, M. Nicolas and E. Doris, Org. Chem. Front., 2017, 4, 1276
    DOI: 10.1039/C7QO00140A

Search articles by author

Spotlight

Advertisements