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Enantioselective synthesis of a cyclobutane analogue of Milnacipran

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Abstract

The asymmetric synthesis of a cyclobutane analogue of the antidepressant drug Milnacipran is reported. The optically active derivative incorporates a central cyclobutane ring in lieu of the cyclopropane unit classically found in Milnacipran. The two stereogenic centres borne by the cyclobutane were sequentially installed starting from phenylacetonitrile.

Graphical abstract: Enantioselective synthesis of a cyclobutane analogue of Milnacipran

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Publication details

The article was received on 20 Feb 2017, accepted on 23 Mar 2017 and first published on 23 Mar 2017


Article type: Research Article
DOI: 10.1039/C7QO00140A
Citation: Org. Chem. Front., 2017, Advance Article
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    Enantioselective synthesis of a cyclobutane analogue of Milnacipran

    D. Nguyen, E. Gravel, D. Buisson, M. Nicolas and E. Doris, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00140A

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