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Ruthenium(II)-catalyzed C–H alkenylation/annulation cascade for the rapid synthesis of benzoimidazoisoindoles

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Abstract

An efficient one pot synthesis of benzimidazole-fused isoindoles from 2-arylbenzimidazole and readily available conjugated alkenes has been explored. The developed domino strategy involved the ruthenium-catalyzed formation of two distinct C–C and C–N bonds and one new five-membered ring to afford a polycyclic molecule. The rapid and base-free reaction conditions and the broader substrate scope are salient features of this novel protocol. The ruthenium-catalyzed tandem reaction provides a direct tool for the easy and rapid access to a new benzoimidazoisoindole scaffold.

Graphical abstract: Ruthenium(ii)-catalyzed C–H alkenylation/annulation cascade for the rapid synthesis of benzoimidazoisoindoles

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Publication details

The article was received on 18 Feb 2017, accepted on 10 Apr 2017 and first published on 11 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00136C
Citation: Org. Chem. Front., 2017, Advance Article
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    Ruthenium(II)-catalyzed C–H alkenylation/annulation cascade for the rapid synthesis of benzoimidazoisoindoles

    M. Selvaraju, Y. Wang and C. Sun, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00136C

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