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Issue 7, 2017
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Asymmetric amination of 2-substituted indolin-3-ones catalyzed by natural cinchona alkaloids

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Abstract

The natural quinine-catalyzed enantioselective amination of 2-substituted indolin-3-ones with azodicarboxylates has been developed. These reactions provide a broad spectrum of 2,2-disubstituted indolin-3-ones containing a nitrogen-attached quaternary stereocenter at the C2-position in extremely high yields and with excellent enantioselectivities. The readily available catalyst, broad substrate scope, and mild reaction conditions highlight the practical utility of this process.

Graphical abstract: Asymmetric amination of 2-substituted indolin-3-ones catalyzed by natural cinchona alkaloids

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Publication details

The article was received on 15 Feb 2017, accepted on 17 Apr 2017 and first published on 18 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00129K
Citation: Org. Chem. Front., 2017,4, 1400-1406
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    Asymmetric amination of 2-substituted indolin-3-ones catalyzed by natural cinchona alkaloids

    J. Guo, Z. Lin, K. Chen, Y. Xie, A. S. C. Chan, J. Weng and G. Lu, Org. Chem. Front., 2017, 4, 1400
    DOI: 10.1039/C7QO00129K

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