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Asymmetric Amination of 2-Substituted Indolin-3-ones Catalyzed by Natural Cinchona Alkaloids

Abstract

The natural quinine-catalyzed enantioselective amination of 2-substituted indolin-3-ones with azodicarboxylates have been developed. These reactions provide a broad spectrum of 2,2-disubstituted indolin-3-ones containing a nitrogen-attached quaternary stereocenter at the C2-position in extremely high yields and excellent enantioselectivities. The readily available catalyst, broad substrate scope, and mild reaction condition highlight the practical utility of this process.

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Publication details

The article was received on 15 Feb 2017, accepted on 17 Apr 2017 and first published on 18 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00129K
Citation: Org. Chem. Front., 2017, Accepted Manuscript
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    Asymmetric Amination of 2-Substituted Indolin-3-ones Catalyzed by Natural Cinchona Alkaloids

    J. Weng, J. Guo, Z. Lin, K. Chen, Y. Xie, A. S. C. Chan and G. Lu, Org. Chem. Front., 2017, Accepted Manuscript , DOI: 10.1039/C7QO00129K

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