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Copper-catalyzed gem-difluoromethylenation of C(sp2)–H bonds of alkenes

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Abstract

Copper-catalyzed gem-difluoromethylenation of the C(sp2)–H bonds of alkenes with high functional group tolerance has been developed. This protocol is the first to efficiently achieve gem-difluoromethylenation of C(sp2)–H bonds of unactivated aliphatic terminal olefins and can be applied in a reaction cascade to achieve gem-difluoromethylenation/cyclization of alkenes.

Graphical abstract: Copper-catalyzed gem-difluoromethylenation of C(sp2)–H bonds of alkenes

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Publication details

The article was received on 11 Feb 2017, accepted on 09 Mar 2017 and first published on 10 Mar 2017


Article type: Research Article
DOI: 10.1039/C7QO00119C
Citation: Org. Chem. Front., 2017, Advance Article
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    Copper-catalyzed gem-difluoromethylenation of C(sp2)–H bonds of alkenes

    H. Xu, D. Wang, Y. Chen, W. Wan, H. Deng, K. Ma, S. Wu, J. Hao and H. Jiang, Org. Chem. Front., 2017, Advance Article , DOI: 10.1039/C7QO00119C

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