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Issue 7, 2017
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Synthesis of 1,4-enyne-3-ones via palladium-catalyzed sequential decarboxylation and carbonylation of allyl alkynoates

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Abstract

Herein we describe a novel protocol for the rapid assembly of 1,4-enyne-3-ones from isocyanides and 1,6-enyne. During this process, two different types of C–C bonds were formed on the same isocyanide carbon atom via sequential decarboxylation, insertion of isocyanide, and reductive elimination. Moreover, this approach shows advantages of mild reaction conditions and excellent functional group compatibility.

Graphical abstract: Synthesis of 1,4-enyne-3-ones via palladium-catalyzed sequential decarboxylation and carbonylation of allyl alkynoates

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Publication details

The article was received on 29 Jan 2017, accepted on 31 Mar 2017 and first published on 05 Apr 2017


Article type: Research Article
DOI: 10.1039/C7QO00082K
Citation: Org. Chem. Front., 2017,4, 1363-1366
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    Synthesis of 1,4-enyne-3-ones via palladium-catalyzed sequential decarboxylation and carbonylation of allyl alkynoates

    Z. Li, J. Zheng, W. Hu, J. Li, W. Wu and H. Jiang, Org. Chem. Front., 2017, 4, 1363
    DOI: 10.1039/C7QO00082K

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